![]() ![]() Drugs such as steroidal anti-inflammatory drugs (SAID) and non-steroidal anti-inflammatory drugs (NSAID) are usually utilized for the treatment of acute inflammatory complaints ( 3, 4). Inflammation could be classified into two groups, acute and chronic inflammation, and each possesses certain types of treatments. Inflammation is generally characterized by redness, edema, fever, and pain, which might bring about loss of organ function dealing with the involved tissue ( 2). It must be controlled precisely since insufficiencies or excesses of the inflammatory response could cause morbidity, shorten lifetime and decrease quality of life ( 1). Inflammation is a local, protecting reaction to injury or microbial invasion. The Symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action. This review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. The papers with the English language were gathered from 2000 to 2021. This review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. Preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several Symphytum species. Symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. The Symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. ![]()
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